연락처 contact
전화 : +82-2-2123-2751
팩스 : +82-2-312-6401
E-mail : haam@yonsei.ac.kr
연구실 : http://nbsl.yonsei.ac.kr/
교수님 소개 introdution
함승주 교수는 국내에 나노바이오 융합연구 분야를 세계적인 수준으로 끌어올려 인간질병극복을 위한 새로운 진단/치료 기술을 개발하는 첨단 나노메디신 분야의 대표적인 선도학자로 인정받고 있다. 특히 지능형 나노하이브리드의 설계 및 제조 기술을 기반으로 한 맞춤형 항암 표적 진단/치료기술 개발에 이어 현재는 첨단 바이러스 진단기술 개발을 통해 조류독감 바이러스 조기 검출키트 상용화에도 그 연구 영역을 넓히고 있다.
함 교수는 최근 5 년간 매년 평균 15 편을 상회하는 SCI 논문을 발표했으며, 논문의 피인용 횟수는 약 2000 회에 이른다. 표지 논문/하이라이트 및 초청 해설 논문으로 선정된 연구결과는 10여 편이 넘는 등 뛰어난 연구업적을 보여주고 있다. 이러한 연구 성과를 인정받아 2011년 국가개발우수성과 100선, 연세대학교 언더우드 특훈 교수 임명(2012), 2014년 과학기술진흥유공자(국무총리 표창)에 선정된 바 있다. 현재 다수의 국가 대형 연구 사업단을 기획 및 유치, 운영함과 동시에 보유한 특허기술들을 약 1억 2천만 원 규모로 기술이전 하는 등 산업계와도 긴밀한 연계활동을 하고 있다.
주요연구 과제 research
아미노산 복합물질의 동질이상체 결정화에 대한 연구, 학술진흥재단 협동연구과제, 2001.10-2003.9
Drowning-out을 사용한 L-proline 결정화 공정 개발 및 연구, 생명공학연구소과제, 2001.3-2002.3
아미노산 결정화에서 첨가제에 의한 결정형상 변화에 대한 연구
의약용 아미노산 및 효소단백질의 결정화 연구
3-D PTV 기술을 이용한 침전반응공정에서의 유동현상해석 및 PBM modeling을 통한 turbulent micromixing effect에 대한연구 2001.3-2002.2
3-D PTV 기술을 이용한 magnetic field MEMS에서의 microflow 해석
Biotechnology를 이용한 Immoblilized enzyme 반응과 그 해석
전산유체역학을 이용한 고분자 전해질 연료전지의 성능향상에 대한 simulation
연구분야 research field
3-D Visualization Techniques, Design and Scale-up of Stirred Vessel Reactor, Development of water treatment process
주요논문 papers
-국외전문학술지-
Seyoung Moon, Dong Jun Kim, Kyujung Kim, Donghyun Kim, Hosub Lee, Kangtaek Lee, Seungjoo Haam, ‘Surface-enhanced plasmon resonance detection of nanoparticle-conjugated DNA hybridization’ APPLIED OPTICS, 2010, 49, 484-491.
Eunjung Kim, Yukyung Jung, Hyangtae Choi, Jaemoon Yang, Jin-Suck Suh, Yong-Min Huh, Kunhong Kim, Seungjoo Haam, ‘Prostate cancer cell death produced by the co-delivery of Bcl-xL shRNA and doxorubicin using an aptamer-conjugated polyplex’ 2010, 31, 4592-4599.
Jaemoon Yang, Jaewon Lee, Jinyoung Kang, Seung Jae Oh, Hyun-Ju Ko, Joo-Hiuk Son, Kwangyeol Lee, Jin-Suck Suh, Yong-Min Huh, Seungjoo Haam, ‘Smart Drug-Loaded Polymer Gold Nanoshells for Systemic and Localized Therapy of Human Epithelial Cancer’ Advanced Materials 2009, 10.1002/adma.200900334.
Taeyun Kwon, Jinsung Park, Jaemoon Yang, Dae Sung Yoon, Sungsoo Na, Chang-Wan Kim, Jin-Suck Suh, Yong-Min Huh, Seungjoo Haam, Kilho Eom, ‘Nanomechanical In Situ Monitoring of Proteolysis of Peptide by Cathepsin B’ Plos One 2009, 10.1371/journal.pone.0006248.s005.
Joseph Park, Jaemoon Yang, Jaemin Lee, Eun-Kyung Lim, Jin-Suck Suh, Yong-Min Huh, Seungjoo Haam, ‘Synthesis and Characterization of Fluorescent Magneto Polymeric Nanoparticles (FMPNs) for Bimodal Imaging Probes’ Journal of Colloid and Interface Science 2009, 340 (2), 176-181.
Eunjung Kim, Jaemoon Yang, Jihye Choi, Jin-Suck Suh, Yong-Min Huh and Seungjoo Haam, ‘Synthesis of Gold Nanorod-Embedded Polymeric Nanoparticles by a Nanoprecipitation Method for Use as Photothermal Agents’ Nanotechnology 2009, 20, 365602-365609.
Huiyul Park, Jaemoon Yang, Jaemin Lee, Seungjoo Haam, In-hong Choi, Kyung-hwa Yoo, ‘Multifunctional Nanoparticles for Combined Doxorubicin and Photothermal Treatments’ ACS Nano 2009, 10.1021/nn900215k.
Hong Jae Lee, Sung Eun Kim, Il Keun Kwon, Chiyoung Park, Chulhee Kim, Jaemoon Yang, Sang Cheon Lee, ‘Spatially mineralized self-assembled polymeric nanocarriers with enhanced robustness and controlled drug-releasing property’ Chemical Communications 2009, 10.1039/b913732g (Cover).
Eun-Kyung Lim, Jaemoon Yang, Jin-Suck Suh, Yong-Min Huh, Seungjoo Haam, ‘Self-labeled magneto nanoprobes using tri-aminated polysorbate 80 for detection of human mesenchymal stem cells’ Journal of Materials Chemistry 2009, in publishing.
Kilho Eom, Jaemoon Yang, Jinsung Park, Gwonchan Yoon, Young Soo Sohn, Shinsuk Park, Dae Sung Yoon, Sungsoo Na and Taeyun KwonExperimental and Computational Characterization of Biological Liquid Crystals: A Review of Single-Molecule Bioassays International Journal of Molecular Sciences 2009, 10(9), 4009-4032.
Jinyoung Kang, Jaemoon Yang, Jaewon Lee, Seung Jae Oh, Seyoung Moon, Hong Jae Lee, Sang Cheon Lee, Joo-Hiuk Son, Donghyun Kim, Kwangyeol Lee, Jin-Suck Suh, Yong-Min Huh,Seungjoo Haam, 'Gold-layered calcium phosphate plasmonic resonants for localized photothermal treatment of human epithelial cancer'of Materials Chemistry Seung Jae Oh, Jinyoung Kang, Inhee Maeng, Jin-Suck Suh, Yong-Min Huh, Seungjoo Haam, and Joo-Hiuk Son, ‘Nanoparticle-enabled terahertz imaging for cancer diagnosis’ OPTICS EXPRESS 2009, 17, 3469-3475.
Sang-Eun Park, Jea-Won Lee, Seung-Joo Haam, and Sang-Wha Lee, ‘Fabrication of double-doped magnetic silica nanospheres and deposition of thin gold layer’ 2009, 30, 869-872.
Jung-Juu Park, Yeena Shin, Jeong-Hoon Oh, Chan-Hwa Chung, Yong-Jung Huh, Seungjoo Haam, ‘The development of a fully integrated micro-channel fuel processor using low temperature co-fired ceramic (LTCC)’ 2009, 15, 618-623.
Jaemin Lee, Jaemoon Yang, Choong-Hwan Lee, Hyun-Ju Ko, Jin-Suck Suh, Yong-Min Huh and Seungjoo Haam, ‘Smart nano-probes for ultrasensitive detection of breast cancer via magnetic resonance imaging’ Nanotechnology 2008, 19 , 485101-485109.
Jaemoon Yang, Kilho Eom, Eun-Kyung Lim, Jinsung Park, Yoonah Kang, Dae Sung Yoon, Sungsoo Na, Eui Kwan Koh, Jin-Suck Suh, Yong-Min Huh, Tae Yun Kwon, Seungjoo Haam, ‘In situ Detection of Live Cancer Cell by using Bio-Probes Based on Au Nanoparticles’, Langmuir 2008, 18, 4402-4407.
Sung-Baek Seo, Jaemoon Yang, Eun-Sook Lee, Yukyung Jung, Kyujung Kim, Sang-Yup Lee, Donghyun Kim, Jin-Suck Suh, Yong-Min Huh,Seungjoo Haam, ‘Nanohybrids via polycation-based nanoemulsion method for dual-mode detection of human mesenchymal stem cells’, Journal of Materials Chemistry 2008, 18, 4402-4407 (Cover).
Eun-Kyung Lim, Jaemoon Yang, Mee-ye Park, Joseph Park, Jin-Suck Suh, Ho-Geun Yoon, Yong-Min Huh, Seungjoo Haam, ‘Synthesis of water soluble PEGylated magnetic complexes using mPEG-fatty acid for biomedical applications’ Colloids and Surfaces B : Biointerfaces 2008, 64, 111-117.
Jaemoon Yang, Eun-Kyung Lim, Hong Jae Lee, Joseph Park, Sang Cheon Lee, Kwangyeol Lee, Ho-Geun Yoon, Jin-Suck Suh, Yong-Min Huh, Seungjoo Haam, ‘Fluorescent Magnetic Nanohybrids as Multimodal Imaging Agents for Human Epithelial Cancer Detection’Biomaterials 2008, 29(16), 2548-2555.
Jaemoon Yang, Jaewon Lee, Jinyoung Kang, Jin-Suck Suh, Ho-Geun Yoon, Yong-Min Huh, Seungjoo Haam, ‘Hollow Silica Nanocontainers as Drug Delivery Vehicles’ Langmuir 2008, 24(7), 3417-3421.
Sung-Baek Seo, Jaemoon Yang, Tong-Il Lee, Yong Jin Song, Jin-Suck Suh, Ho-Geun Yoon, Yong-Min Huh, Seungjoo Haam, ‘Enhancement of Magnetic Resonance Contrast Effect from Controlling Magnetic Cluster Size by Capping of Ionic Surfactants on Magnetic Nanocrystals’ Journal of Colloid and Interface Science 2008, 319,
Jaemoon Yang, Jaewon Lee, Jinyoung Kang, Kwangyeol Lee, Jin-Suck Suh, Ho-Geun Yoon, Yong-Min Huh, Seungjoo Haam, ‘Magnetic sensitivity enhanced novel fluorescent magnetic silica nanoparticles for biomedical applications’ Nanotechnology 2008, 19, 075610-075615.
Huiyul Park, Jaemoon Yang, Sungbaek Seo, Kyujung Kim, Jinsuk Suh, Donghyun Kim, SeungjooHaam, Kyung-Hwa Yoo, ‘Multifunctional Nanoparticles for Photothermally Controlled Drug Delivery and Magnetic Resonance Imaging Enhancement’ Small 2008, 4(2), 192-196.
Jaewon Lee, Jaemoon Yang, Hyunju Ko, Seung-Jae Oh, Jinyoung Kang, Juhiuk Son, Kwangyeol Lee, Sang-Wha Lee, Ho-Geun Yoon, Yong-Min Huh, and Seungjoo Haam, ‘Multifunctional Magnetic Gold Nanocomposites: Breast Cancer Detection via Magnetic Resonance Imaging and Localized Synchronous Therapy’ Advanced Functional Materials 2008, 18(2), 258-264. Jaemoon Yang, Eun-Jin Cho, Sungbaek Seo, Jae-Won Lee, Ho-Geun Yoon, Jin-Suck Suh, Yong-Min Huh, Seungjoo Haam, ‘Enhancement of cellular binding efficiency and cytotoxicity using polyethylene glycol base triblock copolymeric nanoparticles for targeted drug delivery’, Journal of Biomedical Materials Research A 2008, 84A(1), 273-280.
Sungbaek Seo, Jaemoon Yang, Woochan Hyung, Eun-Jin Cho, Yongjin Song, Ho-Geun Yoon, Jin-Suck Suh, Yong-Min Huh and Seungjoo Haam, ‘Novel multifunctional PHDCA/PEI nano-drug carriers for simultaneous magnetically-targeted cancer therapy and diagnosis using magnetic resonance imaging’ Nanotechnology 2007, 18, 475105-475112 (Highlights article). Jaemoon Yang, Choong-Hwan Lee, Hyun-Ju Ko, Jin-Suck Suh, Ho-Geun Yoon, Kwangyeol Lee, Yong-Min Huh, and Seungjoo Haam, ’Multifunctional Magneto-Polymeric Nanohybrids for Targeted Detection and Synergistic Therapeutic Effects on Breast Cancer’Angewandte Chemie International Edition 2007, 46(46), 8836-8839.
Yukyung Jung, Hyo-Jin Park, Pyung-Hwan Kim, Jaewon Lee, Woochan Hyung, Jaemoon Yang, Joo-Hyuk Sohn, Joo-Hang Kim, Chae-Ok Yun and Seungjoo Haam, ‘Retargeting of Adenoviral Gene Delivery via Herceptin-PEG-Adenovirus Conjugates to Breast Cancer Cells’, Journal of Controlled Release 2007, 123, 164?171.
Jaemoon Yang, Jaemin Lee, Bumjun Cha, Yongjin Song, Ho-Geun Yoon, Yong-Min Huh, Seungjoo Haam, ‘Motions of magnetic nanosphere under the magnetic field in the rectangular microchannel’, Journal of Magnetism and Magnetic Materials 2007, 317, 34-40.
Jaemoon Yang, Tong-Il Lee, Jaemin Lee, Eun-Kyung Lim, Woochan Hyung, Choong-Hwan Lee, Yongjin Song, Jin-Suck Suh, Ho-Geun Yoon, Yong-Min Huh, Seungjoo Haam, ‘Synthesis of Ultrasensitive Magnetic Resonance Contrast Agents for Cancer Imaging Using PEG-Fatty Acid’, Chemistry of materials 2007, 19(16), 3870-3876.
Jaemoon Yang, Choong-Hwan Lee, Sungbaek Seo, Eun-Kyung Lim, Yongjin Song, Jin-Suck Suh, Ho-Geun Yoon, Yong-Min Huh, Seungjoo Haam, ‘Antibody Conjugated Magnetic PLGA Nanoparticles for Diagnosis and Treatment of Breast Cancer’, Journal of Materials Chemistry 2007, 17, 2695-2699 (Hot paper).
J.-O. YOU, S.-B. PARK, H.-Y. PARK, S.-J. HAAM, and W.-S. KIM "Preparation of regular sized Ca-alginate microspheres using membrane emulsification method " Journal of Microencapsulation 2000 18 521-532
Sung-Wook Choi. Jeoung-Yeol Yoon, Seungjoo Haam, Joon-Ki Jung, Jung-Hyun Kim, and Woo-Sik Kim "Modeling of the Permeate Flux during Microfiltration of BSA-Adsorbed Microspheres in a Stirred Cell" J. of Colliod and Interface Science 2000 28 270-278
S.J. Haam, R. S. Broodkey "Motions of dispersed beads obtained by particle tracking velocimetry measurements Part Ⅱ" International J. of Multiphase Flow 2000 26 1419-1438
S.J. Haam, R. S. Broodkey I. Fort, L. Klaboch, M. Placnick, V. Vanecek " Laser Doppler anemometry measurements in an index of refraction matched column in the presence of dispersed beads PartⅠ" International J. of Multiphase Flow 2000 26 1401-1418
HO-YEON LEE, KEE-KAHB KOO, SEUNGJOO HAAM, SUN-HWAN KIM, HYOUN-SOO KIM AND BANG-SAM PARK "Effect of Ultrasound on Recrystallization of 3-Nitro-1,2,4-triazole-5-one" J. of Chem. Eng. of Japan 2000 33 842-847
Seong-Bae Park, Jin-Oh You, Ham-Yong Park, Seung Joo Haam, Woo-Sik Kim "A novel pH-sensitive membrane from chitosan - TEOS IPN; preparation and its drug permeation characteristics" Biomaterials 2001 22 323-330
J.-H. Kim, Y.-K. Ryu, S. Haam, C.-H. Lee, and W.-S. Kim "Adsorption and steam regeneration of N-hexane, MEK, and Toluene on activated Carbon fiber" Seperation Science and Technology 2001 36 263-281
J. KANG, C-H LEE, S. HAAM, K. K. KOO AND W-S. KIM(Korea) "Studies on the overall oxygen transfer rate and mixing time in pilot-scale surface aeration vessel" Environmental Technology Volume 22, Number 9, page 1055-1068
M. LEE, J. KANG, C-H. LEE, S. HAAM,HUN-HWEE PARK AND W-S. KIM "Oxygen transfer characteristics in a pilot scale surface aeration vessel with simcar aerator" Environmental Technology 2001 22 57-68
Dae-Won Park, Hae-Sung Kim, Joon-Ki Jung, Seungjoo Haam & Woo-Sik Kim "Enzymetic Synthesis of Alkylglucosides by Amphiphilic Phase Enzyme Reaction" Biotechnology Letters 2000 22 951-956
Jeffrey J. Chalmers, Seungjoo Haam, Yang Zhao, Kara McCloskey, Lee Moore, Macij Zborowski, P. Stephen Williams "Quantification of Cellular Properties from External Fields and Resulting Induced Velocity; Cellular Hydrodynamic Diameter" Biotechnology and Bioengineering 1999 64 509-518
Jeffrey J. Chalmers, Seungjoo Haam, Yang Zhao, Kara McCloskey, Lee Moore, Macij Zborowski, P. Stephen Williams "Quantification of Celluar Properties from External Fields Resulting Velocity; Magnetic Suceptibility" Biotechnology and Bioengineering 1999 64 519-526
S.W LEE, S.J. HAAM, J.W. KWAK, J.H. JANG, AND Y.C. LEE "Ultrafiltration of Desizing Wastewater Containing PVA in Pilot Scale Test" Environmental Technology 1999 20 277-283
Yehoon Kim, Seungjoo Haam, Kee-Kahb Koo, Yong Gun Shul, Joo Hiuk Son, and Joon Ki Jung "Representation of Solid-Liquid Equilibrium of L-Ornithine-L-Aspartate + Water + Methanol System Using Chen Model for Mixed Solvent Electrolyte Solution" J. Chem. Eng. Data 2001, 46, 1387-1391
Dae-Won park, Ji-seok Kim, Seungjoo-Haam, Hae-sung Kim & Woo Sik Kim "Lipase-catalyzed synthesis of B-methylglucoside esters containing and a-hydroxy acid" Biotechnology Letters 2001 23 1947-1952
-국내전문학술지-
유진오, 박성배, 박함용, 함승주, 김중현, 김우식 "유화법을 이용한 Ca-alginate Microsparticle 약물수송체의 제조와 약물방출" HWAHAK KONGHAK 1999 37 789-784
최성욱, 윤정열, 함승주, 정준기, 김우식 "Stirred Cell 안에서의 BSA의 흡착과정에 의해 응집된 Microsphere가 투과 Flux에 미치는 영향 고찰" HWAHAK KONGHAK 2000 38 26-31
Jong-Hwa Kim, Ok-Kyun Oh, Seungjoo Haam, Chang-Ha Lee and Woo-Sik Kim "Adsorptopn and Thermal Regeneration of Toluene and Bezene on the Fixed Bed Packed with Acitivated Carbon and Acitivated Carbon Filter." Carbon Science 2001 2 44-54
김승수, 박대원, 김소영, 김종화, 함승주, 김응빈, 김우식 "Biofliter를 이용한 VOC 처리 특성 및 미생물 첨가에 의한 영향" HWAHAK KONGHAK 2001 39
