사업단 구성

참여교수

장재형교수님 사진

학위 degrees

BS: Chemical Engineering, Yonsei University, 1999
PhD: Chemical and Biological Engineering, Northwestern University, 2005

교수과목 lecture

분석화학, 공학정보처리

연락처 contact

전화 : 82-2-2123-2756
팩스 : 82-2-312-6401
E-mail : j-jang@yonsei.ac.kr
연구실 : http://web.yonsei.ac.kr/mcel - GS칼텍스 산학협력관 201호

교수님 소개 introdution

Northwestern University에서 tissue engineering과 non-viral gene delivery를 세부전공으로 하여 “Non-viral gene delivery from polymer scaffolds for promoting tissue formation" 라는 논문제목으로 2005년 박사학위를 받았습니다. 박사학위후 2005년부터 2009년 1월까지 University of California, Berkeley에서 post-doctoral fellow로 재직하면서 organic nanoparticles (adeno-associated viral vectors)를 사용하여 embryonic or adult stem cell내에서의 gene targeting을 도모하여 좀더 효율적이며 안전하게 stem cell을 control할 수 있는 방법을 개발하였습니다. 또한, 박사후과정으로 재직중, 미국 California정부 산하의 California Institute for Regenerative Medicine으로부터 2006년부터 2008년까지 post-doctoral fellowship을 수여받고 줄기세포관련 연구에 매진하였습니다. 현재의 관심분야는, 줄기세포의 안전성 문제를 해결하고 효율적으로 통제함으로써 현대의학에 조속히 적용할 수 있는 기술의 개발, nano-organic (or synthetic) materials (viral or non-viral vectors)를 이용한 biosensor, 조직공학, 암진단 및 치료제의 개발, neurodegenerative disorders 관련 질환 치료제의 개발에 있습니다.

주요연구 과제 research

- Stem cell therapy

- Tissue regenerative medicine

- Non-viral & viral gene therapy

- Controlled drug delivery

- Nano-biotechnology

- Cancer therapy

- Gene targeting

- Human disease models

주요논문 papers

1. J.H.Jang, J.T. Koerber, and D.V. Schaffer, “Enhancing gene targeting efficiency by directed evolved adeno-associated viral vectors for adult neural stem cells”, manuscript in preparation
2. J.H.Jang, J.T. Koerber, and D.V. Schaffer, “Homologous recombination in genomic DNA of human embryonic stem cells using genetically engineered adeno-associated viral gene delivering vectors”, manuscript in preparation
3. J.H.Jang, J.T. Koerber, and D.V. Schaffer, “Surface-mediated delivery of hexahistidine tagged adeno-associated virus to enhance gene transfer to stem cells”, manuscript in preparation
4. J.T. Koerber, J.H.Jang, andD.V.Schaffer, “DNA shuffling of adeno-associated virus yields functionally diverse progeny”, Molecular Therapy,16(10),p1703-1709,2008
5. J.T. Koerber, R. Klimczak, J.H. Jang, D. Dalkara, J. Flannery, and D.V.Schaffer, "Molecular Engineering of Adeno-associated Virus for Enhanced Glial Gene Delivery” submitted
6. J.H. Jang, K.I. Lim, and D.V. Schaffer, “Library Selection and Directed Evolution Approaches to Engineering Targeted Viral Vectors”, Biotechnology and Bioengineering,98(3),p515-524,2007
7. J.T. Koerber, J.H.Jang, J.H. Yu, R.S. Kane, and D.V. Schaffer, “Engineering adeno-associated virus for one step purification via immobilized metal affinity chromatography”, Human Gene Therapy, 18(4), p367-378, 2007
8. T. L. Houchin, L. A. Swift, J.H.Jang, and L.D.Shea, “Patterned PLG substrates for localized DNA delivery and directed neurite extension”, Biomaterials, 28(16), p2603-2611, 2007
9. J.H. Jang and D.V. Schaffer, “Microarraying the cellular microenvironment”, Molecular Systems Biology, 2:39, 2006
10. J.H. Jang and L.D. Shea, “Intramuscular delivery of DNA releasing microspheres: microsphere properties and transgene expression”, Journalof Controlled Release,112(1),p120-128,2006
11. J.H. Jang, Z. Bengali, T.L. Houchin, and L.D. Shea, “Surface adsorption of DNA to tissue engineering scaffolds for efficient gene delivery”, Journal of Biomedical Materials Research, 77(1), p50-58, 2006
12. Z. Bengali, A.K. Pannier, T. Segura, B.C. Anderson, J.H.Jang, T.A.Mustoe, and L.D.Shea,“Gene delivery through cell culture substrate adsorbed DNA complexes”, Biotechnology and Bioengineering, 90:p290-302, 2005
13. J.H. Jang, C. Rives, and L.D. Shea, “Plasmid delivery in vivo from porous tissue-engineering scaffolds: Transgene expression and cellular transfection”, Molecular Therapy, 12(3):p475-483, 2005
14. Y. Yang, L. Laporte, C. Rives, J.H.Jang, W.C.Lin, K.Shull, and L.D.Shea,“Neurotrophin releasing single and multiple lumen nerve conduits”, Journal of Controlled Release,104 (3): p433-446, 2005
15. J.H.Jang, T.L.Houchin, and L.D.Shea, “Gene delivery from polymer scaffolds for tissue engineering”, Expert Reviews of Medical Devices, 1(1): p127 ? 138, 2004
16. J.H. Jang and L.D. Shea, "Controllable delivery of non-viral DNA from porous scaffolds”, Journal of Controlled Release, 86(1):p157-168, 2003
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